May 5, 2010
RE: Request for MSTS research proposals
Dear MSTS member:
The society’s leadership has set aside monies ($50K) designated specifically for the purpose of fostering MSTS directed research activities. While the society has performed notable cooperative projects in the past, the entire MSTS membership is a unique resource whose potential has yet to be fully realized. Please take some time to consider submitting a proposal. The research committee has identified several priority areas for clinical investigation (attached) and a preference will be given to proposals addressing these disease areas, although other ideas are welcome. Applicants may wish to investigate innovative means of leveraging research activities using infrastructure provided by www.orthopaedia.com or working with existing cooperative groups (e.g., COG, SARC).
To submit a proposal, a simple description of the idea (no longer than 1-2 pages) is required and should convey the background, specific hypothesis, objective, study design, rationale, any known preliminary data, criteria for inclusion/exclusion, treatment plan/protocol, feasibility and estimated cost. A study template is attached. Study ideas will be judged upon scientific merit, impact, feasibility, timeline, correlative science and cost. Please submit applications to Richard Terek, MD, at:
The deadline for submission is July 31, 2010.
Applications will be reviewed by the research committee. Suitable proposals will be recommended for funding to the executive committee who makes the final funding decision. Announcement of funding would be made at the Annual meeting in Philadelphia.
Research and contribution to our field is a most important goal of the society. Please seriously consider how you might join in this endeavor.
Sincerely yours,
Richard Terek, MD
Research Committee Chair
Clinical research priorities
- Randomized trial of GCT treatment
o Curettage with PMMA packing +/- bisphosphonate in cement and IV pre and post op
o Denusomab (Amgen)
- Randomized trial of PVNS: 1) anterior arthroscopic + posterior open
synovectomy vs. 2) anterior open + posterior open synovectomy 3) Synovectomy
+/- radiation therapy
- Randomized trial comparing functional outcome of solitary bone metastatic
lesions treated by internal fixation +/- intralesional excision, zometa impregnated
cement packing
- Randomized trial comparing local recurrence of desmoid tumors after marginal
excision: 1) without radiation vs. 2) with radiation
- Randomized trial comparing endoprosthetic reconstruction with IM rodding of
proximal femur metastatic disease of the femur
- Perioperative prophylactic antibiotic duration for limb salvage (endoprosthetic
and allograft)
